✨ Mismatch repair (MMR) is a cellular DNA repair system that fixes errors that happen during DNA replication.

✨ What MMR Does:

◾ Corrects base-base mismatches

◾ Fixes insertion/deletion loops

✨ How MMR Works:

1️⃣ Recognition: Proteins like MSH2-MSH6 or MSH2-MSH3 recognize the mismatch.

2️⃣ Recruitment: These proteins recruit MLH1-PMS2, which helps bring in other repair factors.

3️⃣ Excision: The incorrect DNA segment is cut out.

4️⃣ Resynthesis: DNA polymerase fills in the correct bases using the original (template) strand.

5️⃣ Ligation: DNA ligase seals the final nick.

✨ Why MMR Is Important:

◾ Prevents mutations from being passed on during cell division.

◾ Defects in MMR genes can lead to microsatellite instability (MSI), a hallmark of certain cancers.

◾ Hereditary mutations in MMR genes (like MLH1, MSH2, MSH6, PMS2) cause Lynch syndrome, increasing the risk of colorectal and other cancers.

✨ Diagnosis:

◾ MMR IHC staining – checks for the presence or absence of MMR proteins in tumor tissue.

◾ If any MMR proteins are missing, genetic testing is often recommended to confirm Lynch syndrome.

✨ We, Dartmon, provide the best-in-class MMR IHC antibodies.

✔️ Our MMR IHC antibodies have gotten excellent level from UKNEQAS assessment.

✔️ Moreover, our MMR IHC antibodies have CE and FDA certifications.