Cytokeratin 5&6 Antibody (DA045)
Cytokeratin 5&6 Antibody (DA045)
Recombinant monoclonal rabbit antibody
Description
Twenty identified cytokeratins make up a complex family of intermediate filaments.1 Cytokeratin 5 (58kDa) & cytokeratin 6 (56kDa) are type II high molecular weight keratins that are expressed in a broad range of normal tissues including breast, prostate, mesothelium, skin and esophagus.1-3 Anti-Cytokeratin 5 & 6 is a useful immunohistochemical marker in the identification of mesothelioma and lung squamous cell carcinoma.1 Combined with 34bE12 and P504S, it can help diagnosis of benign and malignant prostate lesions.
References
1. Ordóñez NG. Value of cytokeratin 5/6 immunostaining in distinguishing epithelial mesothelioma of the pleura from lung adenocarcinoma. Am J Surg Pathol. 1998; 22:1215-21
2. Takahashi K, et al. Cloning and characterization of multiple human genes and cDNAs encoding highly related type II keratin 6 isoforms. J Biol Chem. 1995; 270:18581-92.
3. Lersch R, et al. Isolation, sequence, and expression of a human keratin K5 gene: transcriptional regulation of keratins and insights into pairwise control. Mol Cell Biol. 1989; 9:3685-97.
2. Takahashi K, et al. Cloning and characterization of multiple human genes and cDNAs encoding highly related type II keratin 6 isoforms. J Biol Chem. 1995; 270:18581-92.
3. Lersch R, et al. Isolation, sequence, and expression of a human keratin K5 gene: transcriptional regulation of keratins and insights into pairwise control. Mol Cell Biol. 1989; 9:3685-97.
Specifications
Application:
IHC (FFPE)
Host:
Rabbit
Subclass:
IgG
Immunogen:
Synthetic peptide of human Cytokeratin 5&6
Cellular location:
Cytoplasm
Control:
Prostate
Order information
| RMB1A014 | Concentrate | IVD(R) |
| RMB1A014 | 10 ml Ready to use | IVD(R) |
| RMB1A014 | 6 ml Ready to use | IVD(R) |
| RMB1A014 | 3 ml Ready to use | IVD(R) |
