DOG1 Antibody (DA050)
DOG1 Antibody (DA050)
Recombinant monoclonal rabbit antibody
Description
DOG1 is a calcium-dependent chloride channel protein that is encoded by a gene called TMEM16A (TMEM16 FLJ10261, ANO1, ORAOV2, and AOS2) located on chromosome 11q13.1 DOG1 has many significant functions such as regulation of the cholinergic activity of gastrointestinal smooth muscle 2, 3 and regulation of both the survival and proliferation of cells.4 Anti-DOG1 antibody has been shown to be useful in the identification of gastrointestinal stromal tumors (GIST).5
References
1. Kang HG, et al. DOG1 and PKC-θ are useful in the diagnosis of KIT-negative gastrointestinal stromal tumors. Mod Pathol. 2011; 24:866-77.
2. Rizzo FM, et al.Parallelism of DOG1 expression with recurrence risk in gastrointestinal stromal tumors bearing KIT or PDGFRA mutations. BMC Cancer. 2016; 16:87
3. Katoh M, et al. FLJ10261 gene, located within the CCND1- EMS1 locus on human chromosome 1q13, encodes the eighttransmembrane protein homologous to C12orf3, C11orf25 and LJ34272 gene products. Int J Oncol. 2003; 22:1375-81.
4. Stanich JE, et al. Ano1 as a regulator of proliferation. Am J Physiol Gastrointest Liver Physiol. 2011; 1044-51.
5. Guler B, et al. Histopathological features of gastrointestinal stromal tumors and the contribution of DOG1 expression to the diagnosis. Balkan Med J. 2015; 32:388-96.
2. Rizzo FM, et al.Parallelism of DOG1 expression with recurrence risk in gastrointestinal stromal tumors bearing KIT or PDGFRA mutations. BMC Cancer. 2016; 16:87
3. Katoh M, et al. FLJ10261 gene, located within the CCND1- EMS1 locus on human chromosome 1q13, encodes the eighttransmembrane protein homologous to C12orf3, C11orf25 and LJ34272 gene products. Int J Oncol. 2003; 22:1375-81.
4. Stanich JE, et al. Ano1 as a regulator of proliferation. Am J Physiol Gastrointest Liver Physiol. 2011; 1044-51.
5. Guler B, et al. Histopathological features of gastrointestinal stromal tumors and the contribution of DOG1 expression to the diagnosis. Balkan Med J. 2015; 32:388-96.
Specifications
Application:
IHC (FFPE)
Host:
Rabbit
Subclass:
IgG
Immunogen:
Synthetic peptide from human DOG1
Cellular location:
Cytoplasm/Cell membrane
Control:
Gastrointestinal stromal tumor(GIST)
Order information
| RMA1A017 | Concentrate | IVD(R) |
| RMA1A017 | 10 ml Ready to use | IVD(R) |
| RMA1A017 | 6 ml Ready to use | IVD(R) |
| RMA1A017 | 3 ml Ready to use | IVD(R) |
