p40 Antibody (DA094)
p40 Antibody (DA094)
Recombinant monoclonal rabbit antibody
Description
p40 is an isoform of p63, a transcription factor that regulates many cell activities, including cell proliferation, maintenance, and differentiation. It performs as a sensitive and specific tool for aiding in the identification of squamous cell carcinoma of the lung. In addition to its utility as a squamous differentiation marker, p40 has also been proven to be a valuable marker for highlighting myoepithelial and basal cell populations in prostate, breast, skin, and salivary gland.1-5 Strong p40 expression is frequently observed in esophageal cancerous squamous lesions.6 Immunohistochemical detection of p40 can also be helpful in identifying urothelial carcinoma.7 In cases of prostate carcinoma, p40 is almost always found to be negative for basal cell staining.8
References
2. Alomari, Ahmed K et al. "p40 is a more specific marker than p63 for cutaneous poorly differentiated squamous cell carcinoma." Journal of cutaneous pathology vol. 41,11 (2014): 839-45. doi:10.1111/cup.12388
3. Pelosi, Giuseppe et al. "The impact of immunohistochemistry on the classification of lung tumors." Expert review of respiratory medicine vol. 10,10 (2016): 1105-21. doi:10.1080/17476348.2017.1235975
4. Walia, Ritika et al. "p40 & thyroid transcription factor-1 immunohistochemistry: A useful panel to characterize non-small cell lung carcinoma-not otherwise specified (NSCLC-NOS) category." The Indian journal of medical research vol. 146,1 (2017): 42-48. doi:10.4103/ijmr.IJMR_1221_15
5. Affandi, Khairunisa Ahmad et al. "p40 Immunohistochemistry Is an Excellent Marker in Primary Lung Squamous Cell Carcinoma." Journal of pathology and translational medicine vol. 52,5 (2018): 283-289. doi:10.4132/jptm.2018.08.14
6. Geddert, Helene et al. "The role of p63 and deltaNp63 (p40) protein expression and gene amplification in esophageal carcinogenesis." Human Pathology. 34,9 (2003): 850-856. doi: 10.1016/s0046-8177(03)00342-3.
7. Brandler, Tamar C et al. "Usefulness of GATA3 and p40 immunostains in the diagnosis of metastatic urothelial carcinoma in cytology specimens." Cancer cytopathology vol. 122,6 (2014): 468-73. doi:10.1002/cncy.21424
8. Brustmann, Hermann. "p40 as a Basal Cell Marker in the Diagnosis of Prostate Glandular Proliferations: A Comparative Immunohistochemical Study with 34betaE12." Pathology research international vol. 2015 (2015): 897927. doi:10.1155/2015/897927
Specifications
Order information
| RMA1A023 | Concentrate | IVD(R) |
| RMA1A023 | 10 ml Ready to use | IVD(R) |
| RMA1A023 | 6 ml Ready to use | IVD(R) |
| RMA1A023 | 3 ml Ready to use | IVD(R) |
