CD38 Antibody (DA023)
CD38 Antibody (DA023)
Recombinant monoclonal rabbit antibody
Description
CD38 molecule is a 46-kDa type-II transmembrane glycoprotein with a short N-terminal cytoplasmic tail (20 amino acids) and a long extracellular domain (256 amino acids). It is present on many hematopoietic cells, especially plasma cells, and in some solid tumor tissues.1-3 CD38 is one of the early expressed markers of mature naive B-cell activation and it is useful in identifying functional mature B-lymphocyte subsets.1-3 CD38-positive B-lymphoblastic lymphoma/chronic lymphocytic leukemia has a poor prognosis.
References
1. Martin, Flavius, and John F Kearney. "Marginal-zone B cells." Nature reviews. Immunology vol. 2,5 (2002): 323-35.
2. Dono, M et al. "Heterogeneity of tonsillar subepithelial B lymphocytes, the splenic marginal zone equivalents." Journal of immunology (Baltimore, Md. : 1950) vol. 164,11 (2000): 5596-604.
3. Malavasi, Fabio et al. "Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology." Physiological reviews vol. 88,3 (2008): 841-86.
2. Dono, M et al. "Heterogeneity of tonsillar subepithelial B lymphocytes, the splenic marginal zone equivalents." Journal of immunology (Baltimore, Md. : 1950) vol. 164,11 (2000): 5596-604.
3. Malavasi, Fabio et al. "Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology." Physiological reviews vol. 88,3 (2008): 841-86.
Specifications
Application:
IHC (FFPE)
Host:
Rabbit
Subclass:
IgG
Immunogen:
Synthetic peptide of human CD38
Cellular location:
Cell membrane
Control:
Tonsil
Order information
| RMB1A058 | Concentrate | IVD(R) |
| RMB1A058 | 10 ml Ready to use | IVD(R) |
| RMB1A058 | 6 ml Ready to use | IVD(R) |
| RMB1A058 | 3 ml Ready to use | IVD(R) |
