Anti-CD79a recognizes the Ig-alpha protein of the B-cell antigen component of the B-lymphocyte antigen receptor.^1,3 Anti-CD79a is generally used to complement CD20. This antibody will stain many of the same lymphomas as CD20, but also is more likely to stain precursor B-cell lymphoblastic lymphoma/leukemia. Anti-CD79a also stains more cases of plasma cell myeloma and occasionally some types of endothelial cells as well.