MSH6 Antibody (DA084)
MSH6 Antibody (DA084)
Recombinant monoclonal rabbit antibody
Description
MSH6, also known as MutS homologue 6, is a key protein in DNA mismatch repair system. Mutations in MSH6 gene may lead to microsatellite instability (MSI) caused by accumulation of errors in DNA replication during cell proliferation. MSI is associated with Hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome), which is characterized by the development of colorectal cancer, endometrial cancer and various other tumors at early age. Antibody MSH6 is useful in detection of MSI, especially ina panel with MSH2, PMS2 and MLH1. 1-3
References
1. Edelbrock MA, Kaliyaperumal S and Williams KJ(2013): Structural, molecular and cellular functions of
MSH2 and MSH6 during DNA mismatch repair, damage signaling and other noncanonical activities. Mutat Res.743-744:53-66.
2. Vasen HF, Hendriks Y, de Jong AE et al. (2004): Identification of HNPCC by molecular analysis of colorectal
and endometrial tumors. Dis Markers. 20(4-5):207-13.
3. Kawakami H, Zaanan A and Sinicrope FA (2015):Microsatellite instability testing and its role in the management of colorectal cancer. Curr Treat Options Oncol. 16(7):30
MSH2 and MSH6 during DNA mismatch repair, damage signaling and other noncanonical activities. Mutat Res.743-744:53-66.
2. Vasen HF, Hendriks Y, de Jong AE et al. (2004): Identification of HNPCC by molecular analysis of colorectal
and endometrial tumors. Dis Markers. 20(4-5):207-13.
3. Kawakami H, Zaanan A and Sinicrope FA (2015):Microsatellite instability testing and its role in the management of colorectal cancer. Curr Treat Options Oncol. 16(7):30
Specifications
Application:
IHC (FFPE)
Host:
Rabbit
Subclass:
IgG
Immunogen:
Synthetic peptide from human MSH6
Cellular location:
Nucleus
Control:
Tonsil
Order information
| RMB1A077 | Concentrate | IVD(R) |
| RMB1A077 | 10 ml Ready to use | IVD(R) |
| RMB1A077 | 6 ml Ready to use | IVD(R) |
| RMB1A077 | 3 ml Ready to use | IVD(R) |
