Cytokeratin (LMW) Antibody (DA038)
Cytokeratin (LMW) Antibody (DA038)
Recombinant monoclonal mouse antibody
Description
Anti-cytokeratin, low molecular weight antibody labels acidic keratins K10, K14, K15, K16, and K19. Anti-cytokeratin LMW reactivity is seen in most normal and neoplastic cells of epithelial origin. Anti-cytokeratin LMW is a useful immunohistochemical reagent for distinguishing between poorly differentiated carcinomas and non-epithelial neoplasms. 1-5 It labels almost all non-squamous epithelia, especially various single-layer tubular glandular epithelia. It is not expressed in squamous epithelium. Particularly significant positive labeling of epithelial tumors of the breast, pancreas, bile ducts and salivary glands, tumors of endocrine organs (carcinomas and adenomas), liver cancer, endometrial carcinomas, renal carcinomas, neuroendocrine tumors, and other tumors. Bladder transitional cell carcinoma, nasopharyngeal carcinoma, thymoma, and mesothelioma are also positive. The vast majority of squamous carcinomas are negative.6-9
References
2. Weiss RA, et al. Monoclonal antibody analysis of keratin expression in epidermal diseases: a 48- and 56-kdalton keratin as molecular markers for hyperproliferative keratinocytes. J Cell Biol 1984; 98:1397-406.
3. Swanson PE, et al. Heffalumps, jagulars, and cheshire cats. A commentary on cytokeratins and soft tissue sarcomas. Am J Clin Pathol 1991; 95:S2-7.
4. Eusebi V, et al. Keratin-positive epithelioid angiosarcoma of thyroid. A report of four cases. Am J Clin Pathol. 1990; 14:737-47.
5. Dabbs DJ. Diagnostic Immunohistochemistry. Churchhill Livingstone. 2002; 166-74.
6. Lopez-Beltran A, et al. Lymphoepithelioma-like carcinoma of the urinary bladder: a clinicopathologic study of 13 cases. Virchows Arch. 2001; 438:552-7.
7. Kitazawa R, et al. In situ demonstration of parathyroid hormone-related protein mRNA in sclerosing hepatic carcinoma. Virchows Arch. 1999; 435:137-42.
8. Judkins AR, et al. Sensitivity and specificity of antibodies on necrotic tumor tissue. Am J Clin Pathol. 1998; 110:641-6.
9. Demetris AJ, et al. Ductular reaction after submassive necrosis in humans. Special emphasis on analysis of ductular hepatocytes. Am J Pathol. 1996; 149:439-48.
Specifications
Order information
| MMB1A087 | Concentrate | IVD(R) |
| MMB1A087 | 10 ml Ready to use | IVD(R) |
| MMB1A087 | 6 ml Ready to use | IVD(R) |
| MMB1A087 | 3 ml Ready to use | IVD(R) |
