CD7 Antibody (DA032)
CD7 Antibody (DA032)
Recombinant monoclonal rabbit antibody
Description
CD7 antigen is a 40-kDa cell surface glycoprotein that is a member of the immunoglobulin gene superfamily.1,2 It is suggested that CD7 plays a role in T-cell interactions as it is one of the earliest T-cell lineage associated antigens expressed during T-cell ontogeny.2,3 CD7 is expressed in thymocytes, mature peripheral T-cells, natural killer cells, and lymphoid and myeloid progenitors.1,2,4 CD7 can be used to identify primitive T-cell tumors such as lymphoblastic leukemia if antibodies to other T-cell markers are ineffective.
References
1. Stillwell R, et al. T cell signal transduction and the role of CD7 in costimulation. Immunol Res. 2001; 24:31-52.
2. Schanberg LE, et al. Isolation and characterization of the genomic human CD7 gene: structural similarity with the murine Thy-1 gene. Proc Natl Acad Sci USA. 1991; 88:603-7.
3. Chabannon C, et al. Expression of CD7 on normal human myeloid progenitors. J Immunol. 1992; 149:2110-3.
4. Rabinowich H, et al. Expression and function of CD7 molecule on human natural killer cells. J Immunol. 2003; 152: 517-26.
2. Schanberg LE, et al. Isolation and characterization of the genomic human CD7 gene: structural similarity with the murine Thy-1 gene. Proc Natl Acad Sci USA. 1991; 88:603-7.
3. Chabannon C, et al. Expression of CD7 on normal human myeloid progenitors. J Immunol. 1992; 149:2110-3.
4. Rabinowich H, et al. Expression and function of CD7 molecule on human natural killer cells. J Immunol. 2003; 152: 517-26.
Specifications
Application:
IHC (FFPE)
Host:
Rabbit
Subclass:
IgG
Immunogen:
Synthetic peptide of human CD7
Cellular location:
Cell membrane
Control:
Tonsil
Order information
| MMB1A097 | Concentrate | IVD(R) |
| MMB1A097 | 10 ml Ready to use | IVD(R) |
| MMB1A097 | 6 ml Ready to use | IVD(R) |
| MMB1A097 | 3 ml Ready to use | IVD(R) |
