Calcitonin Antibody (DA008)
Calcitonin Antibody (DA008)
Recombinant monoclonal rabbit antibody
Description
Calcitonin (thyrocalcitonin) is a 32 amino acid linear polypeptide hormone that is involved in regulating calcium metabolism.1 It is primarily produced by the parafollicular cells (also known as C cells) of the thyroid gland, though some neuroendocrine cells in other tissues, such as the respiratory and digestive tracts, can also synthesize calcitonin.1,2 Anti-calcitonin immunohistochemistry is an effective way for demonstrating the parafollicular C cells in the thyroid3,4 and the tumors arising from them, including C cell hyperplasia of the thyroid and medullary thyroid carcinoma, a neuroendocrine tumor that originates from C cells.3
References
1. Barrett EJ. The thyroid gland. In: Boron WF, Boulpaep EL, eds. Medical Physiology. A Cellular and Molecular Approach. Updated Second Edition. Philadelphia, PA: Saunders Elsevier; 2012: 1974-1998.
2. Tsutsumi, Y. "Immunohistochemical analysis of calcitonin and calcitonin gene-related peptide in human lung." Human pathology vol. 20,9 (1989): 896-902.
3. Matias-Guiu, Xavier, and Ronald De Lellis. "Medullary thyroid carcinoma: a 25-year perspective." Endocrine pathology vol. 25,1 (2014): 21-9.
4. Fischer, Sandra, and Sylvia L Asa. "Application of immunohistochemistry to thyroid neoplasms." Archives of pathology & laboratory medicine vol. 132,3 (2008): 359-72.
2. Tsutsumi, Y. "Immunohistochemical analysis of calcitonin and calcitonin gene-related peptide in human lung." Human pathology vol. 20,9 (1989): 896-902.
3. Matias-Guiu, Xavier, and Ronald De Lellis. "Medullary thyroid carcinoma: a 25-year perspective." Endocrine pathology vol. 25,1 (2014): 21-9.
4. Fischer, Sandra, and Sylvia L Asa. "Application of immunohistochemistry to thyroid neoplasms." Archives of pathology & laboratory medicine vol. 132,3 (2008): 359-72.
Specifications
Application:
IHC (FFPE)
Host:
Rabbit
Subclass:
IgG
Immunogen:
Synthetic peptide from human calcitonin
Cellular location:
Cytoplasm
Control:
Medullary Carcinoma of Thyroid
Order information
| RPB1A104 | Concentrate | IVD(R) |
| RPB1A104 | 10 ml Ready to use | IVD(R) |
| RPB1A104 | 6 ml Ready to use | IVD(R) |
| RPB1A104 | 3 ml Ready to use | IVD(R) |
