Myoglobin Antibody (DA089)
Myoglobin Antibody (DA089)
Recombinant monoclonal mouse antibody
Description
Immunostaining with anti-myoglobin provides a specific, sensitive, and practical procedure for the identification of tumors of muscle origin. Since myoglobin is found exclusively in skeletal and cardiac muscle and is not present in any other cells of the human body, it may be used to distinguish rhabdomyosarcoma from other soft tissue tumors.1-6
References
1. Mukai K, et al. Localization of myoglobin in normal and neoplastic human skeletal muscle cells using an immunoperoxidase method. Am J Surg Pathol. 1979; 3:373-6.
2. Corson JM, et al. Intracellular myoglobin--a specific marker for skeletal muscle differentiation in soft tissue sarcomas. An immunoperoxidase study. Am J Pathol. 1981; 103:384-9.
3. Brooks JJ. Immunohistochemistry of soft tissue tumors. Myoglobin as a tumor marker for rhabdomyosarcoma. Cancer. 1982; 50:1757-63.
4. Kahn HJ, et al. Immunohistochemical and electron microscopic assessment of childhood rhabdomyosarcoma. Increased frequency of diagnosis over routine histologic methods. Cancer. 1983; 51:1897-903.
5. Furlong MA, et al. Pleomorphic rhabdomyosarcoma in children: four cases in the pediatric age group. Ann Diagn Pathol. 2001; 5:199-206.
6. Furlong MA, et al. Pleomorphic rhabdomyosarcoma in adults: a clinicopathologic study of 38 cases with emphasis on morphologic variants and recent skeletal muscle-specific markers. Mod Pathol. 2001; 14:595-603.
2. Corson JM, et al. Intracellular myoglobin--a specific marker for skeletal muscle differentiation in soft tissue sarcomas. An immunoperoxidase study. Am J Pathol. 1981; 103:384-9.
3. Brooks JJ. Immunohistochemistry of soft tissue tumors. Myoglobin as a tumor marker for rhabdomyosarcoma. Cancer. 1982; 50:1757-63.
4. Kahn HJ, et al. Immunohistochemical and electron microscopic assessment of childhood rhabdomyosarcoma. Increased frequency of diagnosis over routine histologic methods. Cancer. 1983; 51:1897-903.
5. Furlong MA, et al. Pleomorphic rhabdomyosarcoma in children: four cases in the pediatric age group. Ann Diagn Pathol. 2001; 5:199-206.
6. Furlong MA, et al. Pleomorphic rhabdomyosarcoma in adults: a clinicopathologic study of 38 cases with emphasis on morphologic variants and recent skeletal muscle-specific markers. Mod Pathol. 2001; 14:595-603.
Specifications
Application:
IHC (FFPE)
Host:
Mouse
Subclass:
Immunogen:
Cellular location:
Cytoplasm
Control:
