MUM1 Antibody (DA086)
MUM1 Antibody (DA086)
Recombinant monoclonal rabbit antibody
Description
Anti-MUM1 antibody labels a 50kDa, multiple myeloma oncogene-1 (MUM1) protein. MUM1 is encoded by the MUM1/IRF-4 gene, which is mapped to 6q23-25 and identified as a myeloma-associated oncogene.1,2 It is a member of the interferon regulatory factor family of transcription factors and plays an important role in the regulation of gene expression in response to signaling by interferon and other cytokines. MUM1 positive cells express the protein in the nucleus in a diffuse and microgranular pattern. However, some positivity is also observed in the cytoplasm of MUM1-expressing cells. In normal/reactive lymphoid tissues, such as lymph node, this antibody stains plasma cells, some B-cells in the light zone of germinal centers, and a subset of T-cells (T-cells in germinal centers and interfollicular areas).1,3 MUM1 expression has been described in diffuse large B-cell lymphoma (DLBCL).4-5 Anti-MUM1 antibody can stain other B-cell lymphomas such as lymphoplasmacytic lymphoma, chronic lymphocytic leukemia, follicular lymphoma, marginal zone lymphoma, lymphoblastic lymphoma/leukemia, primary effusion lymphoma, DLBCL, Burkitt-like lymphoma, and classical Hodgkin lymphoma.5-7 However, the tumor cells in nodular lymphocyte predominant Hodgkin lymphoma are negative or only weakly positive.8 MUM1 is also expressed in plasma cell myeloma.9
References
2. Grossman A, et al. Cloning of human lymphocyte-specific interferon regulatory factor (hLSIRF/hIRF4) and mapping of the gene to 6p23-25. Genomics. 1996; 37:229-33.
3. Yamagata T, et al. A novel interferon regulatory factor family transcription factor, ICSAT/Pip/LSIRF that negatively regulates the activity of interferon-regulated genes. Mol Cell Biol. 1996; 16:1283-94.
4. Sundram U, et al. Expression of B-cell proliferation marker MUM1 by melanocytic lesions and comparison with S100, gp100 (HMB45) and Melan A. Mod Pathol. 2003; 16:802-10.
5. Hans CP, et al. Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray. Blood. 2004; 103:275-82.
6. Gualco G, et al. MUM1/IRF4: A Review. Appl Immunohistochem Mol Morphol. 2010; 18:301-10.
7. Gualco G, et al. Frequent expression of multiple myeloma 1/interferon regulatory factor 4 in Burkitt lymphoma. Human Pathology. 2009; 40:565-71.
8. Natkunam Y, et al. Analysis of MUM1/IRF4 protein expression using tissue microarrays and immunohistochemistry. Mod Pathol. 2001; 14:686-94.
9. Kempf W, et al. MUM1 expression in cutaneous CD30+ lymphoproliferative disorders: a valuable tool for the distinction between lymphomatoid papulosis and primary cutaneous anaplastic large-cell lymphoma. BR J Dermatol. 2008; 158:1280-7.
Specifications
Order information
| RMF1A109 | Concentrate | IVD(R) |
| RMF1A109 | 10 ml Ready to use | IVD(R) |
| RMF1A109 | 6 ml Ready to use | IVD(R) |
| RMF1A109 | 3 ml Ready to use | IVD(R) |
