c-MYC Antibody (DA048)
c-MYC Antibody (DA048)
Recombinant monoclonal rabbit antibody
Description
c-Myc is a transcription factor that drives the growth and proliferation of cells. c-Myc is amplified in many different solid and hematopoeitic tumors.1-5 Immunohistochemistry for c-Myc protein is used to identify the presence of a c-Myc translocation in various tumors, most frequently to aid in the diagnosis of Burkitt lymphoma.5
References
1. Dang, C V. "c-Myc target genes involved in cell growth, apoptosis, and metabolism." Molecular and cellular biology vol. 19,1 (1999): 1-11.
2. Toon, Christopher W et al. "Immunohistochemistry for myc predicts survival in colorectal cancer." PloS one vol. 9,2 e87456. 4 Feb. 2014
3. Naidu, Rakesh et al. "Protein expression and molecular analysis of c-myc gene in primary breast carcinomas using immunohistochemistry and differential polymerase chain reaction." International journal of molecular medicine vol. 9,2 (2002): 189-96.
4. Yang, Guang et al. "Combined c-Myc and caveolin-1 expression in human prostate carcinoma predicts prostate carcinoma progression." Cancer vol. 103,6 (2005): 1186-94.
5. Bellan, Cristiana et al. "Burkitt lymphoma versus diffuse large B-cell lymphoma: a practical approach." Hematological oncology vol. 27,4 (2009): 182-5.
2. Toon, Christopher W et al. "Immunohistochemistry for myc predicts survival in colorectal cancer." PloS one vol. 9,2 e87456. 4 Feb. 2014
3. Naidu, Rakesh et al. "Protein expression and molecular analysis of c-myc gene in primary breast carcinomas using immunohistochemistry and differential polymerase chain reaction." International journal of molecular medicine vol. 9,2 (2002): 189-96.
4. Yang, Guang et al. "Combined c-Myc and caveolin-1 expression in human prostate carcinoma predicts prostate carcinoma progression." Cancer vol. 103,6 (2005): 1186-94.
5. Bellan, Cristiana et al. "Burkitt lymphoma versus diffuse large B-cell lymphoma: a practical approach." Hematological oncology vol. 27,4 (2009): 182-5.
Specifications
Application:
IHC (FFPE)
Host:
Rabbit
Subclass:
IgG
Immunogen:
Synthetic peptide of human c-MYC
Cellular location:
Cytoplasm/Nucleus
Control:
Tonsil
Order information
| MMB1A111 | Concentrate | IVD(R) |
| MMB1A111 | 10 ml Ready to use | IVD(R) |
| MMB1A111 | 6 ml Ready to use | IVD(R) |
| MMB1A111 | 3 ml Ready to use | IVD(R) |
