Caldesmon Antibody(DA009)
Caldesmon Antibody(DA009)
Recombinant monoclonal rabbit antibody
Description
Caldesmon is a regulatory protein which plays a role in smooth muscle contraction with actin, myosin, tropomyosin, and calmodulin. Anti-caldesmon antibody labels smooth muscle and tumors of smooth muscle.1-3 It also typically shows expression in epithelioid mesothelioma but not in ovarian serous carcinoma.4,5
References
1. Miettinen, Markku, and Jerzy Lasota. "Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis." Archives of pathology & laboratory medicine vol. 130,10 (2006): 1466-78.
2. Watanabe, K et al. "h-Caldesmon in leiomyosarcoma and tumors with smooth muscle cell-like differentiation: its specific expression in the smooth muscle cell tumor." Human pathology vol. 30,4 (1999): 392-6.
3. McCluggage, W Glenn. "A critical appraisal of the value of immunohistochemistry in diagnosis of uterine neoplasms." Advances in anatomic pathology vol. 11,3 (2004): 162-71.
4. Comin, Camilla E et al. "h-Caldesmon, a useful positive marker in the diagnosis of pleural malignant mesothelioma, epithelioid type." The American journal of surgical pathology vol. 30,4 (2006): 463-9.
5. Comin, Camilla E et al. "h-caldesmon, calretinin, estrogen receptor, and Ber-EP4: a useful combination of immunohistochemical markers for differentiating epithelioid peritoneal mesothelioma from serous papillary carcinoma of the ovary." The American journal of surgical pathology vol. 31,8 (2007): 1139-48.
2. Watanabe, K et al. "h-Caldesmon in leiomyosarcoma and tumors with smooth muscle cell-like differentiation: its specific expression in the smooth muscle cell tumor." Human pathology vol. 30,4 (1999): 392-6.
3. McCluggage, W Glenn. "A critical appraisal of the value of immunohistochemistry in diagnosis of uterine neoplasms." Advances in anatomic pathology vol. 11,3 (2004): 162-71.
4. Comin, Camilla E et al. "h-Caldesmon, a useful positive marker in the diagnosis of pleural malignant mesothelioma, epithelioid type." The American journal of surgical pathology vol. 30,4 (2006): 463-9.
5. Comin, Camilla E et al. "h-caldesmon, calretinin, estrogen receptor, and Ber-EP4: a useful combination of immunohistochemical markers for differentiating epithelioid peritoneal mesothelioma from serous papillary carcinoma of the ovary." The American journal of surgical pathology vol. 31,8 (2007): 1139-48.
Specifications
Application:
IHC (FFPE)
Host:
Rabbit
Subclass:
IgG
Immunogen:
Synthetic peptide of human Caldesmon
Cellular location:
Cytoplasm
Control:
Esophagus
Order information
| MMB1A112 | Concentrate | |
| MMB1A112 | 10 ml Ready to use | IVD(R) |
| MMB1A112 | 6 ml Ready to use | IVD(R) |
| MMB1A112 | 3 ml Ready to use | IVD(R) |
