Glypican-3 Antibody (DA064)
Glypican-3 Antibody (DA064)
Recombinant monoclonal mouse antibody
Description
Glypican-3 (GPC3) is a membrane-bound heparin sulfate proteoglycan known to participate in cell growth and differentiation.1 GPC3 expression has been observed in the majority of hepatocellular carcinomas (HCC), but is rarely expressed in non-neoplastic hepatic tissue, making it a useful marker for HCC.1-3 Additionally, this marker is expressed in many yolk sac tumors.1,4
References
1. Kandil DH, et al. Glypican-3 a novel diagnostic marker for hepatocellular carcinoma and more. Adv Anat Pathol. 2009; 16:125-9.
2. Coston WMP, et al. Distinction of hepatocellular carcinoma from benign hepatic mimickers using Glypican-3 and CD34 immunohistochemistry. Am J Surg Pathol. 2008; 32:433-44.
3. Capurro M, et al. Glypican-3: a novel serum and histochemical marker for hepatocellular carcinoma. Gastroenterology. 2003; 125:89-97.
4. Zynger DL, et al. Glypican 3: a novel marker in testicular germ cell tumors. Am J Surg Pathol. 2006; 30:1570-5.
2. Coston WMP, et al. Distinction of hepatocellular carcinoma from benign hepatic mimickers using Glypican-3 and CD34 immunohistochemistry. Am J Surg Pathol. 2008; 32:433-44.
3. Capurro M, et al. Glypican-3: a novel serum and histochemical marker for hepatocellular carcinoma. Gastroenterology. 2003; 125:89-97.
4. Zynger DL, et al. Glypican 3: a novel marker in testicular germ cell tumors. Am J Surg Pathol. 2006; 30:1570-5.
Specifications
Application:
IHC (FFPE)
Host:
Mouse
Subclass:
IgG2a/κ
Immunogen:
Synthetic peptide of human Glypican 3
Cellular location:
Cytoplasm
Control:
Placenta
Order information
| MMB1A125 | Concentrate | IVD(R) |
| MMB1A125 | 10 ml Ready to use | IVD(R) |
| MMB1A125 | 6 ml Ready to use | IVD(R) |
| MMB1A125 | 3 ml Ready to use | IVD(R) |
