CD163 Antibody (DA015)
CD163 Antibody (DA015)
Recombinant monoclonal rabbit antibody
Description
CD163, also known as scavenger receptor cysteine-rich type 1 protein M130,1 is an acute phase-regulated and signal-inducing transmembrane protein,2 found exclusively on cells of monocytic origin.1 CD163 plays a critical role in macrophage clearance and endocytosis of hemoglobin/haptoglobin complexes.2 Therefore, CD163 contributes to the anti-inflammatory response and protects tissues from oxidative and inflammatory hemoglobin.3 Anti-CD163 labels cells of monocytic-macrophage lineage, with expression in bone marrow3 and histiocytic neoplasms.4
References
1. Buechler C, et al. Regulation of scavenger receptor CD163 expression in human monocytes and macrophagesby pro- and antiinflammatory stimuli. J Leukoc Biol. 2000;67:97-103.
2. Kristiansen M, et al. Identification of the haemoglobin scavenger receptor. Nature. 2001; 409:198-201.
3. Etzerodt A, et al. CD163 and inflammation: biological, diagnostic, and therapeutic aspects. Antioxid Redox Signal. 2013; 18: 2352-63.
4. Backe E, Schwarting R, Gerdes J, et al. Ber-MAC3: new monoclonal antibody that defines human monocyte/macrohphage differentiation antigen. J Clin Pathol. 1991; 44:936-45.
2. Kristiansen M, et al. Identification of the haemoglobin scavenger receptor. Nature. 2001; 409:198-201.
3. Etzerodt A, et al. CD163 and inflammation: biological, diagnostic, and therapeutic aspects. Antioxid Redox Signal. 2013; 18: 2352-63.
4. Backe E, Schwarting R, Gerdes J, et al. Ber-MAC3: new monoclonal antibody that defines human monocyte/macrohphage differentiation antigen. J Clin Pathol. 1991; 44:936-45.
Specifications
Application:
IHC (FFPE)
Host:
Rabbit
Subclass:
IgG
Immunogen:
Synthetic peptide of human CD163
Cellular location:
Cytoplasm/Cell membrane
Control:
Tonsil
Order information
| MMB1A130 | Concentrate | IVD(R) |
| MMB1A130 | 10 ml Ready to use | IVD(R) |
| MMB1A130 | 6 ml Ready to use | IVD(R) |
| MMB1A130 | 3 ml Ready to use | IVD(R) |
