CD44 Antibody (DA123)
CD44 Antibody (DA123)
Recombinant monoclonal rabbit antibody
Description
The CD44 family of glycoproteins exists in a number of variant isoforms, the most common being the standard 85-95 kD or hematopoietic variant (CD44s) that is found in mesodermal cells such as hematopoietic, fibroblastic, and glial cells, as well as in some carcinoma cell lines.1 Higher molecular weight isoforms have been described in epithelial cells (CD44v) and are thought to function in intercellular adhesion and stromal binding.1 While many human tumors express CD44, a positive correlation between CD44v expression and tumor dedifferentiation has been demonstrated.2-4 Anti-CD44 may be useful in discrimination of urothelial carcinoma in-situ from non-neoplastic changes in the urothelium.4,5
References
2. East JA, et al. CD44 and its role in tumor progression and metastasis. Eur J Cancer. 1993; 29A:1921-2.
3. Gadalla HA, et al. Expression of CD44 protein in bilharzial and non-bilharzial bladder cancers. BJU Int. 2004; 93:151-5.
4. McKenney JK, et al. Discriminatory immunohistochemical staining of urothelial carcinoma in situ and non-neoplastic urothelium: an analysis of cytokeratin 20, p53, and CD44 antigens. Am J Surg Pathol. 2001; 25:1074-8.
5. Lopez-Beltran A, et al. Urothelial dysplasia of the bladder: diagnostic features and clinical significance. Anal Quant Cytopathol Histpathol. 2013; 35:121-9.
Specifications
Order information
| DMRDB140 | Concentrate | IVD(R) |
| DMRDB140 | 10 ml Ready to use | IVD(R) |
| DMRDB140 | 6 ml Ready to use | IVD(R) |
| DMRDB140 | 3 ml Ready to use | IVD(R) |
