CAM5.2, also known as very low molecular weight cytokeratin, recognizes 48 and 52 kDa human cytokeratins, corresponding to Moll classifications CK7 and CK8, but with a relatively weak response to CK7. Anti-CAM 5.2 reacts with cytokeratins 7 and 8, which are expressed in simple and glandular epithelia and transitional epithelium. Anti-CAM 5.2 reacts with most normal epithelium and with most carcinomas, including those arising in lung, liver, pancreas, GI tract, breast, genitourinary system, female reproductive organs and some endocrine organs.^1,2 This antibody can be used as an aid to identify epithelial differentiation in normal and neoplastic tissues.